![]() ![]() In CD patients, in turn, we observed increased RANKL levels. We have concluded that low OPG levels may be associated with osteoporosis in ulcerative colitis, but it is not correlated with the c.-223C > T polymorphism in the TNFRSF11B gene. Interestingly, average osteoprotegerin levels in CD patients did not significantly differ from those in controls, whereas in ulcerative colitis patients, OPG levels were significantly lower. We have shown, however, that the c.-223T allele was twice as more frequent in Crohn’s disease (CD) patients than among controls (OR = 1.99, P value = 0.009). Our results did not allow determining an unequivocal association between the polymorphic variants of the TNFRSF11B 5′UTR region and a susceptibility to osteoporosis in IBD patients. Odds ratios, 95 % confidence intervals, and P values were calculated using the HWE calculator. Statistical analyses were conducted using Statistica software. Genotyping of the TNFRSF11B polymorphic site was performed by restriction fragment length polymorphism technique. Lumbar spine and femoral neck bone mineral density, T-score, Z-score as well as OPG, RANKL, vitamin D, calcium and interleukin 4 and 10 concentrations were determined for all study subjects. Our study included 198 IBD patients and 41 healthy controls. The aim of our study was to determine whether the c.-223C > T (rs2073617) polymorphism in the 5′UTR region of the gene encoding osteoprotegerin is a functional polymorphism which may change the gene expression and resulting OPG levels, and so be associated with osteopenia and osteoporosis, and impaired bone metabolism in Crohn’s disease and ulcerative colitis patients. However, no such studies exist for osteoporosis related to IBD. The c.-223C > T polymorphism in this gene has been extensively studied in post-menopausal osteoporosis patients. ![]() One of individual determinants of the bone turnover parameters is osteoprotegerin (OPG) encoded by the TNFRSF11B gene. A reduction in bone mineral mass in these individuals is caused not only by inflammatory processes in the bowel, because osteoporosis occurs already in very young IBD patients and in newly diagnosed individuals who have not yet undergone any pharmacological treatment. Osteoporosis is more frequent in inflammatory bowel disease (IBD) patients.
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![]() “Matt Finish, XL Capris, the Warumpi Band… it’s a whole lot of stuff that you don’t think is pub rock. ![]() O’Grady suggests that they “were never really a pub rock band when they were in Australia, and they came back as a theatre act”, but admits that even he was taken by surprise at the reach of compiler David Laing’s project. Some bands, most significantly AC/DC, are notable by their absence from the album. Bunter Band) to art rock (Split Enz) to heavy metal (Heaven) to punk (The Hitmen) to party-flavoured pop rock like Mental as Anything and the Cockroaches and all points in between. While Blood, Sweat and Beers concentrates on many of the harder edged acts like late-period Aztecs, the Angels, Radio Birdman, Rose Tattoo and the bands that spawned or came after them – Buffalo, Coloured Balls, X and the like – the Glory Days CDs contain a vast array of bands playing everything from classic blues (Cyril B. Pub rock’s scope was so tremendous that no single, clearly defined set of guidelines exists for what bands it could be applied to. Punters of both genders were spoiled for choice. “Up in Sydney Rugby League was really trying to attract live crowds and looking at celebrity eventers to get women to come along, but women had absolutely no problem going along to a pub rock gig!” Divinyls “I think that rock had a more vociferous following than even sport did,” O’Grady says. ![]() Rock barns were squeezing in thousands a night. Some games could barely attract more than a few hundred. In the 70s and 80s, it was still struggling for a decent profile. These days, Rugby League dominates all media platforms in Sydney and south east Queensland from February until October. Numbers swelled in accord with the fact that crowds attact a crowd, and it became a cultural thing.” There was no video games – maybe the Atari, but at least not on the scale there is now, the Internet didn’t exist except in the very rareified atmosphere of the military and universities, and so the crowds tended to coalese at music. “There was a unique set of circumstances, not just musical but socio-economic and political, that really created the environment in which pub rock flourished,” he theorises, a point he makes in his extensive liner notes to the Glory Days compile, “and there was also an absence of competing interests. O’Grady, who headed the staff of the influential Rock Australia Magazine in the 70s and 80s, explains how the phenomenon came to be. Rooms like the Whitehorse and the Station in Melbourne and Sydney’s Bondi Lifesaver and Stagedoor Tavern wrote themselves into history as they hosted some of the most successful music acts this country has ever produced. The Thursday paper’s entertainment section was crammed with listings of hundreds of gigs for the upcoming weekend, all over the city and suburbs, and all of them would pull crowds. During the pub rock era, live music was simply everywhere. Nor do they show how devastating its loss has been to the music scene since. Of course, one only has to switch on to rock radio to hear how pub rock continues to dominate the airwaves, but that handful of Oils, Chisel, Oz Crawl and Dragon songs and ‘Take a Long Line’ hardly paint a picture of how immensely powerful a cultural force it was in Australia. Recently, the Molly TV series, the newly-updated edition of Murray Engleheart’s Blood, Sweat & Beers and music releases like the vast and excellent Glory Days of Aussie Pub Rock have helped to rekindle an interest in this most important era of Australian popular music. Then, quite suddenly it seemed, it was over. Pub rock was, in the words of veteran Australian rock writer Anthony O’Grady, “a revolution in Australian popular music”. It dominated the sales charts, filled TV screens and radio airwaves, and the bands who made it filled the pubs across the land every night of the week. Between late 1976 until the early 90s, rock music informed almost every part of Australian musical culture. It latched on in the pubs across the cities and moved into the suburbs and country towns, ebbing and flowing across two decades. In the mid-1970s a musical and social phenomenon took hold of Australian youth.
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The tutorials above cover this aspect but here are a few more links of interest on PBR shaders in particular. ProRender supports Cinema 4D’s standard materials, lights, and cameras but also R19 also includes a PBR WorkflowThere’s a new PBR Material and light options in Cinema 4D R19. Via Lester Banks Physically Based Rendering (PBR) Shaders He explains Bucket Rendering to get around memory limitations with ProRender. Tips on working with large resolutions with ProRenderĪnother from Jonas Pilz. This is a quick tip from Jonas Pilz and he explains how to get rid of Artefacts by lowering the Ray Epsilon setting in ProRender, which is under the general tab. Get Rid of Precision Artefacts in ProRender There is a known critical issue with Redshift for Cinema 4D R21 when running on High Sierra/CUDA. Rick Barrett from Maxon gives some tips for using ProRender. 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This involving picture should leave all but the most jaded viewers with a smile on their face and a lump in their throat. ![]() With: Kad Merad, Cecile de France, Louis-Do de Lencquesaing, Ben, Alberto Sorbelli, Pierre Diot, Christophe Kourotchkine, Stephan Wojtowicz, Garba Tounkara, Herve Pierre, Romain Medioni, Mathias Camberlein.When it comes to inspirational sports movies, the true-life tale “Rise” proves a slam dunk.ĭropping on the heels of Netflix’s Adam Sandler dramedy “Hustle,” another effective if noisier (and fictional) film about the making of an underdog NBA star, “Rise” covers a great deal of compelling physical and emotional territory in less than two hours. Reviewed at Venice Film Festival (competing), Aug. Screenplay, Giannoli, Marcia Romano, based on the novel "L'idole" by Serge Joncour.Ĭamera (color, widescreen, HD), Christophe Beaucarne editor, Celia Lafite Dupont music, Mathieu Blanc-Francard production designer, Francois-Renaud Labarthe costume designer, Nathalie Benros sound (Dolby Digital), Francois Musy, Gabriel Hafner assistant director, Arnaud Esterez casting, Sarah Teper, Leila Fournier. (International sales: Wild Bunch, Paris.) Produced by Edouard Weil. production, in association with Wild Bunch, Studio 37, France 3 Cinema, Scope Pictures, with the participation of Canal Plus, Cine Plus, France Televisions. They all seem aware that they’re more intelligent than the stuff they produce, but hide behind the excuse of “giving the audience what they want.” And they seem willing, if perhaps not always content, to use Martin to this end.Ī Wild Bunch Distribution, Studio 37 (in France) release of a Rectangle Prods., Wild Bunch, Studio 37, France 3 Cinema, Scope Pictures presentation of Rectangle Prods. Martin’s new entourage includes producer Fleur the sleazy married talkshow director (Louis-Do de Lencquesaing) with whom Fleur is having an affair and the channel’s ratings-horny boss (Stephan Wojtowicz). Giannoli excludes any glimpse of what Martin was like before he became known, and throughout the ordeal, the Everyman has just two basic expressions - “Why?” and “Make it stop” - making character development or identification impossible. (Which is pretty much what Woody Allen recently did in his similarly themed Roberto Benigni-starring segment in “From Rome With Love.”) Beyond a clear desire to understand what has happened to him and the certainty that he does not want to be famous, Martin has no personality to speak of. This starting point is intriguing enough, as it offers both a mystery element - why did people start recognizing this single, balding fortysomething who has never done anything to become famous? - and something of a cheeky metaphor for the fact that most people don’t have to possess any particular kind of talent in order to become a media darling, turning the near-constant press coverage of celebrities into a kind of cannibalistic, self-fulfilling prophecy.īut Giannoli, who co-wrote the screenplay with Marcia Romano, seems content to let his clever setup (borrowed from the Serge Joncour novel “L’idole”) just sit there, as if it were a gimmicky short film. The footage subsequently found its way onto the Internet, and suddenly Kazinski, who works at a company that recycles old electronic parts, is a nationwide sensation. ![]() On the air, he recounts how it all started earlier that week, when out of the blue, people started recognizing him on the subway, asking for autographs and taking his picture, with the resulting turmoil filmed by bystanders on their phones. Pic starts in media res, with Kazinksi (Merad) being prepped by redheaded TV producer Fleur (de France) for his appearance on the (fictional) Gallic talkshow “22 heures en direct,” presented by Albin (real-life tube host Ben). ![]() Whether it's Miyuki's struggle to learn a new skill with the help of Chika or Ishigami's awkwardness causing embarrassment, the humor feels in line with what we expect from this quintet and yet impossible to see coming at the same time. Additionally, all five of the leads are balanced, and the writers seem even more confident in these characters than they did in the first two seasons. We just don't know how they'll get there, and the journey is a fantastic achievement alone. We know their end game is becoming a couple without admitting they're both emotionally vulnerable. These supportive friends, and the series, recognize the mistakes Kaguya and Miyuki make along the way inherent in the relationship they so desperately desire. Their emotional support is endearing, and Hayasaka mainly develops as a multi-faceted individual. Hayasaka and Kei ground Kaguya and Miyuki in reality respectively when needed. Kaguya and Miyuki's worlds may seem like their own, filled with more spontaneous fantasies and lovesick visions than ever, but the real people in the student council surrounding them bring them back to Earth. The endless supply of memorable frames, slick editing, and symbolic imagery make it a gloriously ambitious anime production. Much creative inspiration as Shinichi Omata has to all three seasons. Its perfection is partly thanks to the hilarious cast of loveable characters and production. The jokes are never easy or predictable, and the comedy emerges from a finely-tuned combination of unpredictable narrative turns and how much we know these characters after the first two seasons. The writing in Kaguya-sama remains some of the sharpest on television, balancing physical humor with hysterical scenarios. We define the meaning of these words ourselves, and to me, Kaguya-sama: Love is War - Ultra Romantic is subjectively perfect. Ultimately, we perceive art as beautiful, exciting, and hilarious. Comedy tends to be subjective, as they say. ![]() A geometric compass is a mathematical tool used to calculate the distance between. 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Press Circle to get +5 to Power, Stamina and Heart again. Win the tourney, then punch totals in the last fight. Win the Lightweight, Middleweight, and Heavyweight Online belts. If done correctly you should knock them down and get the trophy after the fight.īecome the champion of two weight divisions in Legacy mode, then reach "G.O.A.T" status. Set the rounds to 2 minutes and choose someone like Foreman. Do the same while fighting Mike Tyson, but with a created boxer. This may also work for the "My Style Is Impetuous" trophy. Just punch him enough to win by decision. Set the round time to 1 minute and up to only round 1. Easy "David and Goliath" and "King of the Rope-a-Dope" trophy.If done correctly you should knock them down and get the achievement or trophy after the fight. ![]() When you load your legacy again, notice that your popularity has been restored and you have not and will not be challenged again. Then, turn exit Legacy mode without saving. 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![]() ![]() To get Metagrossite, return to the Pokemon League and challenge Steven to a rematch. Mega Metagross changes his ability to Tough Claws, which powers up any move that makes physical contact. You'll need Salamencite for this Mega Evolution, which comes from Zinnia's Grandmother in Meteor Falls (after the Delta Episode). Mega Salamence has a similar ability to the two above - Aerilate makes normal moves become flying moves. You'll find the Glalitite in the lower area of the Shoal Cave, in the ice cavern. Mega Glalie sports the super rare Refrigerate ability where normal moves become ice attacks. To get Altarianite, go to Lilycove City and show an Altaria to the collector. Mega Altaria gains the rare Fairy ability Pixilate where normal moves are powered up and turned into Fairy type attacks. Opposite to above, the Cameruptite is in the Magma Hideout during the Delta Episode for Omega Ruby players, but at the Battle Resort in Alpha Sapphire. Mega Camerupt has Sheer Force where attacks are boosted in power but they have no secondary effects (in Camerupt's case, that's probably burning). The Sharpedonite is found in the Team Aqua Hideout during the Delta Episode in Alpha Sapphire, or in the Battle Resort when playing Omega Ruby. Mega Sharpedo uses the ability Strong Jaw which powers up biting moves. The Sablenite stone can be found in Sootopolis City, near the bridge to the Cave of Origin. Mega Sableye gets a big ass diamond and the Magic Bounce ability which reflects non-physical attacks back at the enemy. As above, Swampertite is on Route 120 if you started with Mudkip, or Route 114 if you didn't. Mega Swampert has Swift Swim which boosts your speed in rain. The Sceptilite stone is found on Route 120 if you chose Treecko at the start - otherwise you'll have to buy it from the salesman on Route 114. Mega Sceptile has the Lightningrod ability which means electric attacks do no damage and you get a special attack boost to boot. The required Steelixite can be found in the lower levels of the Granite Cave. Mega Steelix uses Sand Force which increases your power during a sandstorm. You'll need Slowbronite which is yours after you give the man in the Shoal Cave four Shoal Salts and four Shoal Shells. Mega Slowbro is protected from critical hits by its Shell Armor ability. Stone the Intriguing Stone (which you get after giving a Shroomish to the girl in Verdanturf Town). You'll need Pidgeotite, so go to Rustboro City and show Mr. Mega Pidgeot uses No Guard, which massively boosts your accuracy. You can find the necessary Beedrillite in the storage section of the Sea Mauville. Mega Beedrill has the ability Adaptability, which boosts the power of attacks that are the same type as the critter (in this case, bug and poison). And we'll cap it off with the stone locations for the old Mega Evolutions. That boosted Pokemon has new base stats and can have a different ability or even type from its previous form.įor this list we're going to tell you all you need to know about the new Mega Evolutions, including what their new ability does and where you can find their Mega Stone. Then, once per battle, a single Pokémon for each trainer can Mega Evolve. You just need a Mega Bracelet and a compatible Pokemon that's holding an appropriate Mega Stone. Well, the same is true in Omega Ruby and Alpha Sapphire. Remember how, in Pokemon X and Y, you could temporarily boost a Pokemon past its final stage into an awesome Mega Evolution? ![]() ![]() There is no additional charge to you! Some of the amazing following photos are not my own, click on them to head straight to the source!)īesides our actual wardrobe, we also can learn to minimize a lot of the other things we wear regularly.Ġ1 | PAJAMAS. If you purchase a product or service with the links that I provide I may receive a small commission. Ready to figure out how to create your minimalist wardrobe? Follow these easy steps below! Now for the other type of clothing hoarders, the I can’t get rid of anything for that one day, the I spent money on these, or the I can’t get rid of these clothes out of guilt, then aiming for a more minimalist wardrobe might exactly what the doctor ordered. ![]() Whether you are a shopaholic, have to keep up with the latest trends, or consistently partake in retail therapy, then aiming for a more minimalist wardrobe might be a good step in a great direction to control your shopping habits. In reality, those twenty pairs of boots could have maxed out a credit card damaging themselves for their more important future goals. A collection of twenty pairs of boots makes one feel that they are doing “OK” in life. This also falls in direct correlation with our clothes. ![]() People have this preconceived notion that the more they own the more successful they are. When your minimalist wardrobe is only composed of long-lasting things and fits you perfectly, you will feel confident in every single outfit you put on. You will be consistently doing a load of laundry a week, or else you will be out of clothes, BUT just one load on average once a week versus several! Can you imagine? Everything you bring into your wardrobe will now be a wiser and more conscientious choice. You will stop thoughtlessly adding items to your wardrobe on shopping sprees. With fewer clothes to sift through, the faster it will be to find what you’re looking or. Let’s first dive into why you should want one. The overall goal is that you would have a minimal amount of clothing to choose from daily making your life easier and simpler.īefore diving into how to have a minimalist closet. So what exactly is a minimalist wardrobe you may be asking yourself?Ī minimalist wardrobe is where you only keep high-quality, perfectly fitting, neutral pieces of clothing that can easily be mixed and matched with each other. So, in reality, you already have the skillset to have a minimalist wardrobe. We have a habit of choosing to wear the same clothes over and over again. So getting back to that minimalist wardrobe… the truth is you already have one right now in your closet and you don’t even realize it. The worst part about this scenario is that if you were going to a museum opening more than likely, you will want to go buy yourself something new anyways! So that dress you have been holding onto forever for that museum opening is still collecting dust. The problem is trends change, clothes change, and most importantly we change. Sure, in a perfect world we would have the perfect outfit sitting in our closet waiting for its long-awaited debut. The Joy of Less, a beautiful minimalism book, makes an ideal gift for any loved one on a mission to simplify their life.Tweet Why would anyone want a minimalist wardrobe? Isn’t the idea is that you have so many clothes that you can be prepared for any event or any season? Her advice has been featured widely in the media, including on CNN, BBC, Today, and in The New York Times, USA Today, The Chicago Tribune, The Guardian, The Financial Times, Forbes, The Huffington Post, Le Parisien, ELLE Espana, House Beautiful, Woman's World, Dr. Francine has helped hundreds of thousands of people declutter their homes and simplify their lives with her bestselling book, The Joy of Less. Ready to sweep away the clutter? Just open this book, and you'll be on your way to a simpler, more streamlined, and more serene life.
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